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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are often characterized as focusing on practical aspects of design, including recruitment and consent, adherence and the use of routinely available equipment.
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A pragmatic study that involves a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for pragmatic trials to be reliable and lessen the chance of bias, 프라그마틱 추천 is also necessary. However too much heterogeneity could cause issues with the design of the trial.
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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are typically requested by practitioners and policymakers in order to inform their decisions. They can also be used to assess the causal relationship between an intervention with its outcomes. They should not, however, be used to replace explanation studies.
The pragmatism concept is controversial, and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform policy and practice decision-making. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the characteristics of a pragmatic trial, including the recruitment process, the design and implementation of the intervention, as well as monitoring.
There is an encouraging trend in the number of pragmatic trials published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) resulted in 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.
