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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are usually characterized by a focus on practical aspects of the study design, such as the recruitment and consent process, adherence, and the use of commonly available equipment.
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A pragmatic study that involves a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be valid and also reduces the chance of bias in the results. However excessive heterogeneity could result in issues with the design of the trial.
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Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They can also be a great method to determine the causality between the intervention and its effects. However, they should not be used as a substitute for explanatory trials.
The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace explanatory tests or if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis as well as pragmatic trials that inform policy and practice decisions. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the features of a pragmatic study which includes the recruitment process, 프라그마틱 정품인증 (Https://Www.Google.Com.Gi/Url?Q=Https://Blogfreely.Net/Laughchurch0/Why-Pragmatic-Free-Trial-Meta-Is-Relevant-2024) the design and delivery of the intervention, as well as monitoring.
The number of pragmatic trials is increasing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs), yielded 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.
